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细胞毒性T淋巴细胞（CTL细胞）通常称为CD8 + T细胞，是适应性免疫系统的关键组成部分，在免疫系统抵御病原体（如病毒、细菌和肿瘤）中发挥重要作用[1]。辅助性CD4 + T细胞（如Th1、Th2、Th9、Th17、Th22、Tfh和Treg）是在胸腺中生成并表达αβ-T细胞受体或TCR，但与CD4 + T细胞不同的是它们的表面表达CD8 ...

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Mar 17, 2000 · A multiple organ Northern blot revealed T-bet transcripts only in lung, thymus, and spleen, a distribution suggestive of T cell restricted expression (Figure 3A).To examine the kinetics of T-bet protein expression during primary stimulation of T cells, DO11.10 TCR transgenic splenocytes were activated in the presence of Th1- or Th2-inducing conditions …

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